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Vancomycin cefotaxime penetration

Since concentrations in microdialysates and abscesses are not frequently available for humans, this review focuses on drug CSF concentrations. When several equally active compounds are available, a drug which comes close to these physicochemical and pharmacokinetic properties should be preferred. Several anti-infectives e. In many cases, however, pharmacokinetics have to be balanced against in vitro activity. Direct injection of drugs, which do not readily penetrate into the CNS, into the ventricular or lumbar CSF is indicated when other effective therapeutic options are unavailable. Central nervous system CNS infections caused by pathogens with a reduced sensitivity to drugs are a therapeutic challenge. This is particularly true for infections caused by penicillin-resistant pneumococci, methicillin-resistant staphylococci, multiresistant Gram-negative aerobic bacilli, or several other organisms including Aspergillus spp.
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Penetration of antibiotics through Staphylococcus aureus and Staphylococcus epidermidis biofilms.

Vancomycin cefotaxime penetration
Vancomycin cefotaxime penetration
Vancomycin cefotaxime penetration
Vancomycin cefotaxime penetration
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Penetration of antibiotics through Staphylococcus aureus and Staphylococcus epidermidis biofilms.

Since concentrations in microdialysates and abscesses are not frequently available for humans, this review focuses on drug CSF concentrations. When several equally active compounds are available, a drug which comes close to these physicochemical and pharmacokinetic properties should be preferred. Several anti-infectives e. In many cases, however, pharmacokinetics have to be balanced against in vitro activity.
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Most of the patients had diabetic vitreous hemorrhage with or without traction retinal detachments, and some had rhegmatogenous retinal detachments with proliferative vitreoretinopathy. Samples of vitreous were obtained by pars plana vitrectomy at intervals from 46 minutes to 4 hours 13 minutes after the subconjunctival injection. The median vitreous concentrations of all three drugs were below the limit of detection. Vitreous concentrations of these drugs after a single subconjunctival injection are exceedingly low.
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Vancomycin is often combined with a second antibiotic, most often rifampin or gentamicin, for the treatment of serious methicillin-resistant Staphylococcus aureus infections. Published data from experiments evaluating these and other vancomycin-based combinations, both in vitro and in animal models of infection, often yield inconsistent results, however. More importantly, no data are available from randomized clinical trials to support their use, and some regimens are known to have potential toxicities. Clinicians should carefully reconsider the use of vancomycin-based combination therapies for the treatment of infection due to methicillin-resistant S.
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